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Daily use of aspirin over the long term, as with coumadin, eventually causes the cell wall membrane to fail and bleeding is the end result, and it can be uncontrollable in a large number of cases. 

There are so many safe and effective natural supplements and remedies that will help with maintaining "thinned" blood it is puzzling why people subject themselves to these risks.
 "Regular aspirin users at higher risk of sight problems, research suggests" Martin Evans, The Telegraph, 10/3/ uk 
Study after study has shown that daily aspirin use increases the risk of intestinal bleeding and a potentially fatal haemorrhage. Also, a recent study showed some disturbing news for anyone who values their eyesight.
 Dutch researchers examined more than 4,000 elderly patients. Among these patients, 840 took a daily low-dose aspirin. When the researchers compared records, they found that those who used aspirin were TWO TIMES more likely to develop "wet" advanced macular degeneration (AMD) - the advanced form of the disease that sharply increases risk of blindness. 
This does not prove that aspirin promotes wet AMD... but there is a significant link and a very alarming risk that should be taken seriously.
Researchers continued to say that the heart health benefits of aspirin outweigh the AMD risks.
But in a 2005 New England Journal of Medicine study, some 20,000 middle-aged women took 100mg of aspirin daily for 10 years. Another group of nearly the same size took a placebo.
Results showed that aspirin provided no protection from heart attack, but did slightly reduce risk of ischemic stroke. 
Meanwhile, women in the aspirin group were found to have a 40% increased risk of gastrointestinal bleeding severe enough to require transfusions!
Add to that wet AMD and this "wonder drug" may not be worth the risk. 

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